Lack of clinically evident signs of organ failure affects ED treatment of patients with severe sepsis
© Kakebeeke et al; licensee Springer. 2013
Received: 30 September 2012
Accepted: 10 February 2013
Published: 27 February 2013
It is not known whether lack of recognition of organ failure explains the low compliance with the “Surviving Sepsis Campaign” (SSC) guidelines. We evaluated whether compliance was higher in emergency department (ED) sepsis patients with clinically recognizable signs of organ failure compared to patients with only laboratory signs of organ failure.
Three hundred twenty-three ED patients with severe sepsis and septic shock were prospectively included. Multivariable binary logistic regression was used to assess if clinical and biochemical signs of organ failure were associated with compliance to a SSC-based resuscitation bundle. In addition, two-way analysis of variance was used to investigate the relation between the predisposition, infection, response and organ failure (PIRO) score (3 groups: 1–7, 8–14, 15–24) as a measure of illness severity and time to antibiotics with disposition to ward or ICU as effect modifier.
One hundred twenty-five of 323 included sepsis patients with new-onset organ failure were admitted to the ICU, and in all these patients the SSC resuscitation bundle was started. Respiratory difficulty, hypotension and altered mental status as clinically recognizable signs of organ failure were independent predictors of 100% compliance and not illness severity per se. Corrected ORs (95% CI) were 3.38 (1.08–10.64), 2.37 (1.07–5.23) and 4.18 (1.92–9.09), respectively. Septic ED patients with clinically evident organ failure were more often admitted to the ICU compared to a ward (125 ICU admissions, P < 0.05), which was associated with shorter time to antibiotics [ward: 127 (113–141) min; ICU 94 (80–108) min (P = 0.005)].
The presence of clinically evident compared to biochemical signs of organ failure was associated with increased compliance with a SSC-based resuscitation bundle and admission to the ICU, suggesting that recognition of severe sepsis is an important barrier for successful implementation of quality improvement programs for septic patients. In septic ED patients admitted to the ICU, the time to antibiotics was shorter compared to patients admitted to a normal ward.
Recent studies showed that increasing compliance with the “Surviving Sepsis Campaign” (SSC) guidelines is associated with reduced mortality in patients with severe sepsis and septic shock admitted to the ICU [1–4]. Unfortunately, the same studies also report that compliance is low, ranging from 10 to 52% [1–4]. Besides development of new treatment modalities for sepsis, it is equally important to find reasons for non-compliance and optimize implementation of treatment strategies proven to be beneficial. Causes of non-adherence range from physician-based factors, i.e., lack of awareness, to logistic factors, i.e., lack of staffing . Insight in these factors is crucial for successful guideline implementation , because each barrier requires a specific solution. For example, a Dutch tailored intervention project failed to reduce time to antibiotics when targeting logistic barriers in the ED, and administration of antibiotics in the ED instead of the ward reduced time to antibiotics only slightly . In this intervention project, recognition of sepsis was not considered as a possible delaying factor, while this might have been the “bottleneck” and explain why the other measures did not reduce time to antibiotics. Several other studies have investigated behavioral, logistic and economic factors associated with non-adherence [7–9]. Only one retrospective study suggested that lack of recognition of sepsis plays a role in compliance to an SSC-based quality improvement program , while recognition of severe sepsis is the first step in optimizing ED sepsis treatment. In addition, not all patients with severe sepsis are admitted to the ICU, i.e. because of age, erroneous clinical judgment or contraindications for ICU admission. Instead, approximately two-thirds of ED patients with severe sepsis are admitted to a normal ward instead of the intensive care unit (ICU), with clinically evident signs of organ failure less frequently present in the ward admissions . Especially for these patients, recognition of organ failure and optimization of ED treatment are important because not all SSC targets can be attained and optimal ED treatment might prevent progression to more severe stages of sepsis and decrease hospital lengths of stay. Once admitted to a normal ward (and not the ICU), patient monitoring is minimal so that clinical deterioration is easily missed and a potential window of opportunity is lost [11–14].
In the present study, it is hypothesized that septic ED patients with clinically recognizable signs of organ failure, i.e., hypotension, are treated better than patients with only biochemical signs of organ failure, i.e., hyperlactatemia. If recognition of organ failure is the “bottleneck” in compliance to the SSC compared to other aforementioned factors, quality improvement programs should develop specific tools for recognition of biochemical signs of organ failure, because both have similar mortality . The advice to screen for signs of organ failure besides screening for the presence of infection and systemic inflammatory response criteria1 might be insufficient.
The purpose of this study was therefore to assess if compliance is higher in ED sepsis patients with clinically evident signs of organ failure compared to patients with only biochemical signs of organ failure relative to other potential factors that might affect protocol adherence.
Study design and setting
This was a prospective observational cohort study in the EDs of the Medical Centre Haaglanden (MCH, Westeinde), an urban hospital with ~49,000 patients annually, and the Leiden University Medical Centre (LUMC), a tertiary care university hospital with ~26,000 visits per year. Patients were enrolled between 1 November 2007 to 1 March 2011 in MCH and from 1 May 2009 to 1 March 2011 in LUMC. The SSC-based guidelines were implemented later in the LUMC, resulting in a shorter period of inclusion in the academic center. The study was part of a quality improvement program with the aim to implement SSC-based guidelines  and was approved by the medical ethical committee of the MCH. Medical personnel were informed about the study by means of presentations and flyers containing the inclusion criteria and goals to be achieved. In both EDs, one dedicated doctor informed all new nurses and doctors about the campaign. Medical personnel were motivated to attain all ED goals and to consult the ICU if inclusion criteria were met. In the Netherlands, the ED is only managed by qualified ED physicians from 8.00 to 23.00 h during weekdays. During night and weekend shifts, residents of medicine or surgery provide patient care. The ICU physician decided if a patient needed ICU admission.
Selection of participants
All patients with a suspected infection were screened for systemic inflammatory response syndrome (SIRS) and new onset organ failure criteria according to the SSC . Consecutive ED patients, 18 years and older, meeting the criteria for severe sepsis and septic shock were included.
Methods of measurement
Compliance to the SSC resuscitation bundle was quantified by assigning one point to each of the following goals attained: lactate measurement within 6 h, blood cultures before antibiotics, administration of antibiotics within 3 h, mean arterial pressure above 65 mmHg within 6 h, 1.5 l fluid bolus in case of hypotension below 90 mmHg or lactate >4 mmol/l, and ICU consultation to enable completion of the resuscitation bundle of the SSC. In the Netherlands, treatment requiring central venous and arterial catheters is usually performed in the ICU and not in the ED. The Mortality in Emergency Department Sepsis (MEDS) and predisposition, infection, response, and organ failure (PIRO) scores were used to quantify illness severity as described previously [16, 17]. Signs of organ failure as described in the PIRO score were used because these were shown to be associated with mortality.
66 ± 17
68 ± 17
63 ± 16
Malignancy, not metastasized
Respiratory rate (/min)
28 ± 10
27 ± 9
29 ± 10
93 ± 7
90 ± 11
Heart rate (/min)
111 ± 24
110 ± 24
111 ± 25
Systolic BP (mmHg)
105 ± 31
105 ± 30
106 ± 33
58 ± 18
57 ± 18
59 ± 18
Altered mental status
38.1 ± 1.6
38.0 ± 1.4
38.2 ± 1.9
Leucocyte count (10 × 9/l)
14.1 ± 9.9
15.1 ± 9.0
12.9 ± 11.2
248 ± 160
258 ± 149
235 ± 178
1.8 ± 1.5
1.7 ± 1.5
1.9 ± 1.5
22 ± 29
23 ± 33
21 ± 24
3.7 ± 2.6
3.5 ± 2.5
3.9 ± 2.9
C-reactive protein (mg/l)
194 ± 142
183 ± 135
216 ± 151
9.2 ± 5.7
9.4 ± 6.3
8.6 ± 4.0
7.35 ± 0.59
7.32 ± 0.79
7.39 ± 0.10
171 ± 116
175 ± 123
166 ± 106
14.1 ± 10.3
15 ± 11
13 ± 9
Suspected site of infection (%)
Urinary tract infection
Number of acute organ dysfunctions
1.8 ± 0.9
1.7 ± 0.9
1.9 ± 0.9
11.9 ± 4.6
11.8 ± 5.1
12.8 ± 4.3
8.8 ± 4.0
8.5 ± 4.1
9.1 ± 3.8
Fluids in ED (l)
1.9 ± 1.3
1.6 ± 1.1
2.2 ± 1.5
Time to antibiotics (min)
115 ± 91
127 ± 95
94 ± 74
Number of goals attained
4.3 ± 1.4
3.9 ± 1.4
5.1 ± 1.0
All goals attained
ICU consultation in ED
Hospital length of stay (days)
13.1 ± 15.0
10 ± 12
18 ± 19
3.3 ± 8.9
0.5 ± 2.0
8 ± 13.1
9.7 ± 10.4
9.7 ± 10.7
10.0 ± 10.1
Full compliance with the SSC resuscitation bundle was the main outcome measure of the present study. In addition, the effect of illness severity (as determined by the PIRO score) and disposition to ward or ICU on ED treatment was assessed.
Descriptive continuous data are presented as mean ± SD or with 95% confidence intervals, unless indicated otherwise. Continuous variables were tested with Student t-tests. Categorical data were analyzed using X2 tests. To assess predictors of 100% compliance with the resuscitation bundle of the SSC, multivariable binary logistic regression was done with forward entry of variables that had P < 0.2 in univariate analysis. Regardless of the univariate analysis, clinical signs of organ failure, i.e., respiratory difficulty (defined as in PIRO score), initial systolic blood pressure <90 mmHg, altered mental status and febrile chills were entered in the multivariable analysis. Because both clinical and biochemical signs of organ failure are associated with mortality, the laboratory signs of organ failure (lactate > 4 mmol/l, urea >7.14 mmol/l, thrombocytopenia <150.1012/l) were also put in the model . Liver dysfunction due to sepsis occurred in only three patients and was therefore not put in both models. The Hosmer-Lemeshow test was used as a measure of model calibration.
Sample size was based on the generally accepted rule of thumb of the number of events (in our study the number of patients in whom all goals of the SSC resuscitation bundle were attained) divided by ten. Because we wanted to put the aforementioned signs of organ failure in the model regardless of the univariate analysis, we needed ~70 events. In retrospect, merely 5 independent predictors of full compliance were identified and put in the final model, so ~50 events were needed, less than the 77 events in the present study.
To explore the relative impact of quality of ED treatment (as quantified by the number of SSC targets achieved), illness severity (as quantified by the PIRO score ), and disposition to the ward or ICU on mortality in our study cohort with relatively low mortality, we put these three variables in a binary logistic regression model with in-hospital mortality as an outcome measure in a similar way as described above. We expressed the effects of predictor variables on compliance and hospital mortality using odds ratios (ORs) including 95% confidence intervals (CIs).
Finally, because time to antibiotics is an important predictor of mortality [18–20], two-way analysis of variance was used to test if the time to antibiotics depends on illness severity and disposition. ICU admission was considered as a separate indicator of illness severity in addition to the initial PIRO score because it also incorporates the patient’s response to ED treatment. Non-responders to ED fluid resuscitation and patients with severe respiratory failure were expected to be admitted to the ICU.
All data were analyzed using PASW statistics18.0 (IBM, New York, USA) software.
Results and discussion
Factors associated with 100% compliance with the SSC guidelines
Univariate and multivariate analysis of factors related to 100% compliance with the in the ED attainable goals of the resuscitation bundle of the “Surviving Sepsis Campaign”
Corrected OR (95% CI) multivariate
62 ± 17
68 ± 17
Respiratory difficulty (28)
Hypotension <90 mmHg (2)
Altered mental status (15)
Febrile chills (30)
Lactate >4 (58)
Urea >7.14 mmol/l (4)
Total PIRO score
12.9 ± 4.7
12.0 ± 4.9
Total MEDS score
9.1 ± 3.8
8.7 ± 4.1
Academic (as opposed to urban)
Time of ED presentation:
8.00 a.m.–23.30 p.m.
23.30 p.m.–8.00 a.m.
ED physician involved (19)
Medical (the rest being surgical)
The effect of illness severity and disposition on time to antibiotics
Univariate analysis of presence of clinical and laboratory signs of organ failure of septic ED patients admitted to the ward and ICU
Clinically evident signs of organ failure
Altered mental status
Laboratory signs of organ failure
Urea >7.14 mmol/l
Total PIRO score
12.8 ± 4.3
11.8 ± 5.1
The effect of illness severity, compliance and disposition on mortality
PIRO score was 11.5 ± 4.8 in survivors and 14.5 ± 4.1 in non-survivors (P < 0.001). Number of achieved goals was 4.3 ± 1.4 in survivors and 4.5 ± 1.2 in non-survivors (P = 0.379). Eighty-seven (35%) of the survivors were admitted to the ICU compared to 31 (43%) of the non-survivors (P = 0.18). The PIRO score was the only independent predictor of in-hospital mortality in our study cohort with relatively low mortality. The adjusted OR was 1.14 (1.07–1.21) per unit increase in the PIRO score.
There are several limitations to our study. First, we did not register the age and years of experience of the attending physician, while in theory this could affect compliance. However, no studies investigating protocol adherence found an association between years of experience and compliance . More importantly, in the Netherlands the ED is run by relatively young and inexperienced residents. The vast majority of doctors are still in training . Consequently, there is no wide range of age and experience in Dutch EDs, and the assessment of the effect of age and years of experience is therefore difficult to explore.
Second, we could not assess all goals of the resuscitation bundle because the majority of patients were admitted to a normal ward and not to the ICU. In these patients, a central line was never inserted, and the full resuscitation bundle was consequently not provided. Therefore, we scored a point if the ICU was consulted. In addition, our study only supplied data with regard to compliance to the resuscitation bundle and not with the sepsis management bundle.
The present study has two main findings: First, the presence of clinically recognizable signs of organ failure is the most important factor associated with compliance to the resuscitation bundle of the SSC rather than illness severity per se, suggesting that lack of recognition of organ failure in ED patients with severe sepsis and septic shock plays a role in non-compliance to the SSC guidelines.
Secondly, septic ED patients with clinically evident signs of organ failure are more likely to be admitted to the ICU compared to patients with only biochemical signs of organ failure, which is associated with substantially shorter time to antibiotics, despite similar predicted mortality.
Factors associated with 100% compliance with the SSC guidelines
The individual goals of the resuscitation bundle were achieved in 54 to 81% of the patients (Figure 1), but in only 24% all goals were attained despite an extensive Surviving Sepsis Campaign and the advice to start the resuscitation bundle as soon as organ failure was present as a sign of severe sepsis. Patients with clinical evidence of organ dysfunction received better patient care than patients with only laboratory evidence of organ failure, while their predicted mortality is similar since the two and three points in the PIRO score assigned for increased urea and lactate correspond with a similar increase in predicted mortality such as respiratory difficulty, shock and altered mental status (the latter in the MEDS score) [16, 17]. Thus, despite the fact that clinical and laboratory variables give similar odds for mortality, they result in different compliance. Biochemical signs of organ failure were available within 63 min, well within the 3 h SSC target for time to antibiotics. Non-compliance was therefore not caused by waiting for availability of laboratory results. Instead, we hypothesize that clinically more ill-appearing patients are better recognized and are therefore treated better. An important implication of the present study is that EDs should incorporate specific tools for recognition of organ failure in the ED. The three screening questions of the SSC (suspected infection, SIRS criteria, organ failure, ) apparently trigger the attending physician in case of clinically recognizable signs of organ failure, but not when merely laboratory signs of organ failure are present, but these should lead to a similar sense of urgency. The use of information technology could increase the recognition of organ failure by coupling the clinical chemistry database with an electronic patient file that shows a warning when there is a biochemical sign of organ failure. This might be more effective than a simple screening list with signs of organ failure.
The ICU was more often involved in patient care in the LUMC, which might explain the higher odds for full compliance, consistent with the findings of Mikkelson and colleagues who showed that involvement of a severe sepsis service was associated with better compliance with early goal-directed therapy .
Finally, odds for full compliance decreases with a 2%/year increase in age, which is a worrisome finding, especially for older patients with a contraindication for ICU admission (i.e., DNR status) because in these patients optimal ED treatment might be the only treatment significantly improving prognosis. Our findings are consistent with the previously reported age-related differences in delivery of critical care [24, 25], but the underlying etiology is unclear.
The effect of illness severity and disposition on time to antibiotics
Timely administration of antibiotics and adequate fluid resuscitation are critical issues in septic ED patients [18–21]. Illness severity per se, as quantified by the PIRO score, was not associated with protocol adherence or time to antibiotics (Table and Figure 2). However, time to antibiotics was significantly shorter in patients admitted to the ICU, which might be partially explained by the observation that more ED patients with clinically evident signs of organ failure were admitted to the ICU (Table 3). In patients admitted to the ward, time to antibiotics was substantially longer, and this might affect mortality but also hospital length of stay . The larger amount of fluids administered in ICU admitted patients might partially reflect poor responsiveness to fluid resuscitation, necessitating ICU admission, which is supported by the observation that more patients with septic shock are admitted to the ICU instead of the ward (Table 3).
The effect of illness severity, compliance and disposition on mortality
Mortality was not associated with compliance, possibly because our study was underpowered to establish such a relationship. Treatment effect has been shown to depend on illness severity [27–29], which might also explain the absence of a correlation between compliance and mortality since in-hospital mortality was 22% in our study cohort compared to the 37 and 44% in the ICU population of previous studies investigating the effect of compliance to the SSC guidelines in patients admitted to the ICU [1, 2].
In summary, the presence of clinically recognizable signs of organ failure results in better compliance with the “Surviving Sepsis Campaign” compared to laboratory signs of organ failure. Septic ED patients with clinically evident signs of organ failure are more often admitted to the ICU as opposed to the ward, which is associated with shorter time to antibiotics. Recognition of severe sepsis is an important barrier to successful implementation of evidence-based quality improvement programs for ED sepsis patients.
This study met the criteria for exemption from obtaining informed consent, because of the observational character of the study.
We are grateful to all the nurses, senior house officers and residents who were involved in patient inclusion.
- Mitchell MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC, on behalf of the Surviving Sepsis Campaign: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*. Crit Care Med 2010, 38: 367–374. 10.1097/CCM.0b013e3181cb0cdcView ArticleGoogle Scholar
- Ferrer R, Artigas A, Levy MM, Blanco J, Gonza’lez-Dı’az G, Garnacho-Montero J, Iba’n˜ ez J, Palencia E, Quintana M, Victoria de la M, Torre-Prados , for the Edusepsis Study Group: Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 2008,299(19):2294–2303. 10.1001/jama.299.19.2294PubMedView ArticleGoogle Scholar
- Gao F, Melody T, Daniels DF, Giles S, Fox S: The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 2005,9(6):R764-R770. 10.1186/cc3909PubMed CentralPubMedView ArticleGoogle Scholar
- Bryant Nguyen H, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho TW, Wittlake WA: Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007, 35: 1105–1112. 10.1097/01.CCM.0000259463.33848.3DPubMedView ArticleGoogle Scholar
- Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Paul-Andre’ C, Abboud PA, Rubin HR: Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 1999, 282: 1458–1465. 10.1001/jama.282.15.1458PubMedView ArticleGoogle Scholar
- Van Tuijn CFJ, Luitse JS, van der Valk M, Van Wissen S, Prins M, Rosmulder R, Geerlings SE: Reduction of the door-to-needle time for administration of antibiotics in patients with a severe infection: a tailored intervention project. The Netherlands J Med 2010,68(3):123–127.Google Scholar
- Carlbom DJ, Rubenfeld GD: Barriers to implementing protocol-based sepsis resuscitation in the emergency department: results of a national survey. Crit Care Med 2007,35(11):2525–2532. 10.1097/01.ccm.0000298122.49245.d7PubMedView ArticleGoogle Scholar
- Rubenfeld GD: Translating clinical research into clinical practice in the intensive care unit: the central role of respiratory care. Respir Care 2004,49(7):837–843.PubMedGoogle Scholar
- Stoneking L, Denninghoff K, DeLuca L, Keim SM, Munger B: Sepsis bundles and compliance with clinical guidelines. J Intensive Care Med 2011,26(3):172–182. 10.1177/0885066610387988PubMedView ArticleGoogle Scholar
- Cronshaw HL, Daniels R, Bleetman A, Joynes E, Sheils M: Impact of the Surviving Sepsis Campaign on the recognition and management of severe sepsis in the emergency department: are we failing? Emerg Med J 2011, 28: 670–675. 10.1136/emj.2009.089581PubMedView ArticleGoogle Scholar
- De Groot B, de Deckere ERJT, Flameling R, Sandel MH, Vis A: Performance of illness severity scores in guiding disposition of emergency department patients with severe sepsis and septic shock. Eur J Emerg Med 2011. Epub ahead of printGoogle Scholar
- Goldhill DR, Sumner A: Outcome of intensive care patients in a group of British intensive care units. Crit Care Med 1998, 26: 1337–45. 10.1097/00003246-199808000-00017PubMedView ArticleGoogle Scholar
- Lundberg JS, Perl TM, Wiblin T, Costigan MD, Dawson J, Nettleman MD, Wenzel RP: Septic shock: An analysis of outcomes for patients with onset on hospital wards versus intensive care units. Crit Care Med 1998, 26: 1020–4. 10.1097/00003246-199806000-00019PubMedView ArticleGoogle Scholar
- Kennedy M, Joyce N, Howell MD, Mottley JL, Shapiro NI: Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med 2010, 17: 1080–1085. 10.1111/j.1553-2712.2010.00872.xPubMed CentralPubMedView ArticleGoogle Scholar
- Puskarich MA, Trzeciak S, Shapiro NI, Heffner AC, Kline JA, Jones AE: Emergency Medicine Shock Research Network (EMSHOCKNET). Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation 2011,82(10):1289–1293. 10.1016/j.resuscitation.2011.06.015PubMed CentralPubMedView ArticleGoogle Scholar
- Shapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW: Mortality in Emergency Department Sepsis (MEDS) score: A prospectively derived and validated clinical prediction rule. Crit Care Med 2003, 31: 670–675. 10.1097/01.CCM.0000054867.01688.D1PubMedView ArticleGoogle Scholar
- Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI: Proof of principle: The predisposition, infection, response, organ failure sepsis staging system*. Crit Care Med 2011, 39: 322–327. 10.1097/CCM.0b013e3182037a8ePubMedView ArticleGoogle Scholar
- Gaieski DF, Pines JM, Band RA, Mikkelsen ME, Massone R, Furia FF, Shofer FS, Goyal M: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010,38(4):1045–53. 10.1097/CCM.0b013e3181cc4824PubMedView ArticleGoogle Scholar
- Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. J. Infectious Dis. 2006, 19: 3251–258.Google Scholar
- Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE, on behalf of the Emergency Medicine Shock Research Network (EMSHOCKNET): Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011,39(9):2066–71. 10.1097/CCM.0b013e31821e87abPubMed CentralPubMedView ArticleGoogle Scholar
- Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345: 1368–1377. 10.1056/NEJMoa010307PubMedView ArticleGoogle Scholar
- Mikkelsen ME, Gaieski DF, Goyal M, Miltiades AN, Munson JC, Pines JM, Fuchs BD, Shah CV, Bellamy SL, Christie JD: Factors associated with nonadherence to early goal-directed therapy in the ED. Chest 2010, 138: 551–558. 10.1378/chest.09-2210PubMed CentralPubMedView ArticleGoogle Scholar
- Thijssen WAMH, Giesen PHJ, Wensing M: Emergency departments in The Netherlands. Emerg Med J 2012,29(1):6–9. Epub ahead of print 10.1136/emermed-2011-200090PubMedView ArticleGoogle Scholar
- Fowler RA, Sabur N, Li P, Juurlink DN, Pinto R, Hladunewich MA, Adhikari NKJ, Sibbald WJ, Martin CM: Sex- and age-based differences in the delivery and outcomes of critical care. CMAJ 2007,177(12):1513–1519.PubMed CentralPubMedView ArticleGoogle Scholar
- Hamel MB, Lynn J, Teno JM, Covinsky KE, Wu AW, Galanos A, Desbiens NA, Phillips RS: Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults: lessons from SUPPORT. J Am Geriatr Soc 2000,48(5 Suppl):S176–82.PubMedView ArticleGoogle Scholar
- Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG: Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Ann Int Med 2004, 164: 637–644. 10.1001/archinte.164.6.637View ArticleGoogle Scholar
- Clec’h C, Timsit JF, De Lassence A, Azoulay E, Alberti C, Garrouste-Orgeas M, Mourvilier B, Troche G, Tafflet M, Tuil O, Cohen Y: Efficacy of adequate early antibiotic therapy in ventilator acquired pneumonia: Influence of disease severity. Intensive Care Med 2004, 30: 1327–1333. 10.1007/s00134-004-2292-7PubMedView ArticleGoogle Scholar
- Eichacker PQ, Parent C, Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C: Risk and the efficacy of antiinflammatory agents: Retrospective and confirmatory studies of sepsis. Am. J. Resp. Crit. Care Med. 2002, 166: 1197–1205. 10.1164/rccm.200204-302OCPubMedView ArticleGoogle Scholar
- Vincent JL, Opal SM, Marshall JC: Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med 2010, 38: 283–287. 10.1097/CCM.0b013e3181b785a2PubMedView ArticleGoogle Scholar
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