The duration of SIRS before organ failure is a significant prognostic factor of sepsis
© Sugita et al.; licensee Springer. 2012
Received: 29 April 2012
Accepted: 10 December 2012
Published: 31 December 2012
The mortality rate of patients complicated with sepsis-associated organ failure remains high in spite of intensive care treatment. The purpose of this study was to define the duration of systemic inflammatory response syndrome (SIRS) before organ failure (DSOF) and determine the value of DSOF as a prognostic factor in septic patients.
This retrospective cohort study was conducted in an 11-bed medical and surgical intensive care unit (ICU) in a university hospital. The primary endpoint was in-hospital mortality of the septic patients.
One hundred ten septic patients with organ failure and/or shock were enrolled in this study. The in-hospital mortality rate was 36.9%. The median DSOF was 28.5 h. As a metric variable, DSOF was a statistically significant prognostic factor according to univariate analysis (survivor: 74.7 ± 9.6 h, non-survivor: 58.8 ± 16.5 h, p = 0.015). On the basis of the ROC curve, we defined an optimal cutoff of 24 h, with which we divided the patients as follows: group 1 (n = 50) comprised patients with a DSOF ≤24 h, and group 2 (n = 60) contained patients with a DSOF >24 h. There were statistically significant differences in the in-hospital mortality rate between the two groups (52.0% vs. 25.0%, p = 0.004). Furthermore, by multivariate analysis, DSOF ≤24 h (odds ratio: 5.89, 95% confidence interval: 1.46-23.8, p = 0.013) was a significant independent prognostic factor.
DSOF may be a useful prognostic factor for severe sepsis.
KeywordsSevere sepsis Septic shock Systemic inflammatory response syndrome (SIRS) Organ failure Acute Physiology and Chronic Health Evaluation (APACHE) II score
The mortality rate of patients complicated with sepsis-associated organ failure or septic shock remains high in spite of the treatments in intensive care units (ICU) [1, 2]. There are non-responders among the septic patients with poor prognosis whose disease progresses rapidly despite various treatments received in the ICU.
Previous reports show that certain scoring systems, including the Acute Physiology and Chronic Health Evaluation (APACHE) II score, Disseminated Intravascular Coagulation (DIC) score, Sequential Organ Failure Assessment (SOFA) score, and delta SOFA score, predict the prognosis of sepsis [3–5]. However, they sometimes fail to provide a prognosis for identifying high-risk patients with sepsis at an early stage [6, 7].
Sepsis is generally defined as systemic inflammatory response syndrome (SIRS) with infection . In most cases of sepsis, patients only develop SIRS in the early stage, but some of them (approximately 25%) progress to advanced stages of the disease, which entail organ failure and septic shock [9, 10]. However, no study has sufficiently examined the speed of progression from early stage sepsis to organ failure and septic shock in the advanced stages. We defined a novel parameter—the duration of SIRS before organ failure (DSOF) —which denotes the speed of sepsis progression. The purpose of this study was to determine whether DSOF has prognostic value in septic patients complicated with organ failure or shock.
Patients and definition
This retrospective cohort study was conducted in the medical and surgical ICU of a university hospital. The institutional ethics committee approved this study, and all enrollees gave their informed consent. From September 2001 to February 2007, 118 patients were enrolled. They consist of the patients from the general ward of our hospital and patients from other hospitals. They were transferred to the ICU for treatment of sepsis.
Sepsis was defined as an infection with SIRS. Patients were classified according to the American College of Chest Physicians/Society of Critical Care Medicine Sepsis Consensus Conference, 1992 .
We defined SIRS as the presence of at least two of the following criteria: (1) body temperature > 38°C or < 36°C, (2) heart rate > 90 beats/min, (3) respiratory rate > 20 breaths/min or PaCo2 < 32 mmHg, and (4) WBC count > 12,000/μl or < 4,000/μl . When patients fulfilled the criteria of SIRS, the time was recorded as first recognition. Patients who needed to receive mechanical ventilation and/or had serum Cr levels above 4.0 mg/dl or total bilirubin levels above 5.0 mg/dl were considered to have respiratory failure, renal failure, or hepatic failure, respectively. The time of intubation or blood sampling was regarded as the first recognized time of organ failure. We defined shock as systolic blood pressure below 90 mmHg or the necessity of the administration > 5 μgkg-1 min-1 dopamine, dobutamine, or any dose of nor-adrenaline, even if sufficient fluids were infused. When patients fulfilled at least one of the criteria of organ failure or septic shock, the time was recorded as first recognition.
As the treatment of sepsis, removal or drainage of the infection sites and adequate antimicrobial therapy were performed as soon as possible [3, 15–17]. Mechanical ventilation for sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and fluid resuscitation and the administration of catecholamine for maintaining circulation for septic shock are performed in septic patients to prevent the development of a more critical condition resulting in MOF and death [8, 18–20]. The treatment of sepsis was performed according to the Surviving Sepsis Campaign guideline [8, 21] .
The relationship between risk factors and death was first examined by univariate analysis using the two-sample unpaired Student’s t-test for parametric continuous variables, Mann–Whitney U-test for nonparametric continuous variables, and Pearson’s chi-square test for categorical variables. Multivariate logistic regression was performed to determine independent risk factors for in-hospital mortality. Risk factors with p-values < 0.2 by univariate analysis were put into the multivariate logistic regression. The SOFA score was not included in the multivariate analysis because it has a relationship with APACHE II scores. We analyzed the survival between patients with DSOF ≤24 h and DSOF >24 h by using Kaplan-Meier survival curves, and the significance was tested by log-rank test. All statistical analyses were performed using SPSS for Windows (Release 13.0; SPSS Inc., Chicago, IL). Two-tailed p-values <0.05 were considered significant.
Results and discussion
Of the 118 patients who were enrolled initially, we excluded 5 patients who had uncertain records regarding the first recognition of SIRS and 3 patients younger than 15 years. Thus, the final group for evaluation comprised 110 patients. The mean age of the patients (72 men and 38 women) was 63.3 ± 1.4 years (range 16–88 years).
There were 59 (53.6%), 79 (71.8%), and 28 (25.5%) patients with shock, organ failure, and both, respectively. The types of organ failure were respiratory failure (70 patients), renal failure (8 patients), and hepatic failure (3 patients). The mean ICU and mean hospital stays were 15.5 ± 2.4 days and 54.1 ± 5.0 days, respectively. The mean APACHE II and SOFA scores at admission were 22.6 ± 0.7 and 8.92 ± 0.38, respectively. The mean and median DSOFs were 68.9 ± 8.5 h and 28.5 h (range 0–456 h), respectively. The in-hospital mortality rate was 36.9%.
Univariate analysis of risk factors for in-hospital mortality
Non-survivors (n = 41)
Survivors (n = 69)
69.3 ± 1.7
59.7 ± 1.8
APACHE II score
26.6 ± 0.1
20.3 ± 0.8
10.1 ± 0.7
8.3 ± 0.4
4.5 ± 0.32
4.37 ± 0.25
Chronic cardiac insufficiency
Chronic renal insufficiency
Chronic pulmonary insufficiency
Localization of infection
From the general ward in our hospital
First antibiotic sensitivity
14 / 27 (51.9)
22 / 50 (44.0)
Time lag between first detection of SIRS and administration of antibiotics
12.8 ± 3.5
21.5 ± 6.4
11.0 ± 0.6
11.6 ± 0.4
43.3 ± 4.2
32.7 ± 2.7
2.12 ± 0.21
1.64 ± 0.17
3.44 ± 0.77
2.70 ± 0.57
AT III (%)
47.6 ± 3.1
63.1 ± 2.7
412 ± 33
463 ± 18
Platelets (×10 4/μl)
11.6 ± 1.5
13.6 ± 1.6
17.4 ± 1.4
16.6 ± 1.1
31.0 ± 1.2
29.6 ± 0.7
58.8 ± 16.5
74.7 ± 9.6
DSOF (≤ 24 h)
DSOF (≤ 48 h)
Patient characteristics in groups 1 and 2
Group 1 (n = 50)
Group 2 (n = 60)
66.8 ± 1.6
60.3 ± 2.1
32 ( 64.0 )
APACHE II score
23.3 ± 1.0
22.1 ± 0.9
9.88 ± 0.51
8.12 ± 0.52
4.47 ± 0.28
4.38 ± 0.28
32 ( 64.0)
Severe underlying disease
Chronic cardiac insufficiency
Chronic renal insufficiency
Chronic pulmonary insufficiency
Localization of primary infection
AT III (%)
56.6 ± 3.4
57.9 ± 2.9
2.28 ± 0.21
1.43 ± 0.16
41.9 ± 3.6
32.7 ± 3.0
Mortality rate in subgroups
Origin of infection
Group 1 (n = 50)
Group 2 (n = 60)
Biliary tract infection
Bacterial species and DSOF
Number of patients
Number of patients
DSOF ≤24 h
DSOF >24 h
Multivariate analysis of risk factors for in-hospital mortality
In-hospital mortality OR (95% CI)
DSOF (≤ 24 h)
APACHE II score
We developed and defined the DSOF—calculated using clinical parameters—and evaluated its value as a prognostic factor (Figure 1). Our results demonstrate that as a metric variable, DSOF is a significant prognostic factor by univariate analysis and that the in-hospital mortality rate in patients with DSOF ≤24 h is significantly higher than in those with DSOF >24 h. In addition, a DSOF of ≤24 h is an independent prognostic factor in septic patients, as are APACHE II score, AT III levels, age, and primary infection in the lung according to multivariate analysis.
There may be a time lag between true SIRS development and the recognition of SIRS. The time lag may be less than a few hours. This may be a limit of this study. However, no physician can know the true development of SIRS in clinical practice. Thus, we employed the recognition time of SIRS in the present study. DSOF denotes the speed of progression from early to advanced-stage sepsis. Various factors, including host defense and its response to infection, the strength of the bacterial toxin, and treatment efficacy, influence the DSOF. Severe underlying diseases and condition such as diabetes mellitus, liver cirrhosis, and immunosuppression are implicated in the patient’s prognosis, although we did not observe any significance in this study [10, 15, 22–26].
Septic patients with long DSOFs might tolerate bacteria. However, the type of bacteria and toxin is implicated in the DSOF-based prognosis. For example, Streptococcus spp. infection caused a short DSOF and poor prognosis in this study. Thus, the DSOF might reflect the host response and the strength of the bacteria.
The wide range in DSOFs causes the difficulty in statistical evaluation. We defined an optimal cutoff of 24 h with which we divided the patients and compared mortality rates. Further, we compared the characteristics between groups 1 and 2 to determine the factors that influence the DSOF. Age might significantly influence DSOF. The higher incidence of shock in group 1 than group 2 suggests that the progression from SIRS to shock is more rapid than the progression from SIRS to organ failure. The deterioration of renal function in group 1 patients might be attributed to shock. Furthermore, the higher SOFA scores in group 1 might be attributed to renal dysfunction and shock.
We examined various prognostic factors of severe sepsis and septic shock by multivariate analysis and found that age, APACHE II score, AT III, and pneumonia are independent prognostic factors, consistent with previous reports [2, 3, 10, 27]. Our results suggest that the DIC score at the time of ICU admission has no prognostic value, although DIC has been reported to be a prognostic factor of organ failure [14, 22]. These results indicate that the progression of DIC is slower than circulatory failure and respiratory failure in many cases and that early organ failure is not dependent on DIC. We analyzed DSOFs by the primary location of infection. In septic patients in whom the primary infection was the lung, DSOF ≤24 h was a significant prognostic factor of in-hospital mortality. However, our data show that the DSOF in patients with peritonitis was shorter than that in other subgroups, and the mortality rate in patients with DSOF ≤24 h is not greater than in patients with DSOF >24 h. These results indicate that pan-peritonitis progresses more rapidly than other diseases, and the patient’s prognosis may depend on the surgical procedure and treatment after surgery. Analysis of a cohort of septic patients showing different types of sepsis may cause wide variations in DSOF. Thus, additional subgroup analyses are necessary.
DSOF may be dependent on the accuracy of the first detection of sepsis. Thus, the patients with infection should be observed carefully. However, the detection of SIRS in in-patients is not difficult. The Delta SOFA score, which measures the progression of organ failure, is an excellent prognostic factor, but it is not available until a few days after the patients have organ failure and have been admitted to the ICU [28, 29]. In contrast, DSOF can be calculated at the time of recognition of organ failure. DSOF may be a promising prognostic factor for patients with severe sepsis. There is no correlation between the DSOF and APACHE II score. Thus, the combination of DSOF and APACHE II score may be more useful for determining the patients with poor prognosis.
DSOF may be a promising prognostic factor for the patients with severe sepsis. Further clinical studies are necessary.
- Martin GS, Mannino DM, Eaton S, et al.: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348: 1546–1554. 10.1056/NEJMoa022139PubMedView ArticleGoogle Scholar
- Micek ST, Roubinian N, Heuring T, et al.: Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 2006, 34: 2707–2713. 10.1097/01.CCM.0000241151.25426.D7PubMedView ArticleGoogle Scholar
- Garnacho-Montero J, Aldabo-Pallas T, Garnacho-Montero C, et al.: Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care 2006, 10: R111. 10.1186/cc4995PubMed CentralPubMedView ArticleGoogle Scholar
- Cauchie P, Cauchie C, Boudjeltia KZ, et al.: Diagnosis and prognosis of overt disseminated intravascular coagulation in a general hospital – meaning of the ISTH score system, fibrin monomers, and lipoprotein-C-reactive protein complex formation. Am J Hematol 2006, 81: 414–419. 10.1002/ajh.20597PubMedView ArticleGoogle Scholar
- Knaus WA, Draper EA, Wagner DP, et al.: APACHE II: a severity of disease classification system. Crit Care Med 1985, 13: 818–829. 10.1097/00003246-198510000-00009PubMedView ArticleGoogle Scholar
- Park BH, Park MS, Kim YS, et al.: Prognostic utility of changes in N-terminal pro-brain natriuretic Peptide combined with sequential organ failure assessment scores in patients with acute lung injury/acute respiratory distress syndrome concomitant with septic shock. Shoc 2011, 36: 109–114. 10.1097/SHK.0b013e31821d8f2dView ArticleGoogle Scholar
- Charles PE, Ladoire S, Snauwaert A, et al.: Impact of previous sepsis on the accuracy of procalcitonin for the early diagnosis of blood stream infection in critically ill patients. BMC Infect Dis 2008, 8: 163. 10.1186/1471-2334-8-163PubMed CentralPubMedView ArticleGoogle Scholar
- Dellinger RP, Carlet JM, Masur H, et al.: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004, 32: 858–873. 10.1097/01.CCM.0000117317.18092.E4PubMedView ArticleGoogle Scholar
- Dremsizov T, Clermont G, Kellum JA, et al.: Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course? Chest 2006, 129: 968–978. 10.1378/chest.129.4.968PubMedView ArticleGoogle Scholar
- Alberti C, Brun-Buisson C, Chevret S, et al.: Systemic inflammatory response and progression to severe sepsis in critically ill infected patients. Am J Respir Crit Care Med 2005, 171: 461–468.PubMedView ArticleGoogle Scholar
- American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20: 864–874. 10.1097/00003246-199206000-00025View ArticleGoogle Scholar
- Vincent JL, de Mendonca A, Cantraine F, et al.: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European Society of Intensive Care Medicine. Crit Care Med 1998, 26: 1793–1800. 10.1097/00003246-199811000-00016PubMedView ArticleGoogle Scholar
- Gando S, Wada H, Asakura H, et al.: Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients. Clin Appl Thromb Hemost 2005, 11: 71–76. 10.1177/107602960501100108PubMedView ArticleGoogle Scholar
- Gando S, Iba T, Eguchi Y, et al.: A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med 2006, 34: 625–631.PubMedGoogle Scholar
- Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, et al.: Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med 2003, 31: 2742–2751. 10.1097/01.CCM.0000098031.24329.10PubMedView ArticleGoogle Scholar
- Marshall JC, Maier RV, Jimenez M, et al.: Source control in the management of severe sepsis and septic shock: an evidence-based review. Crit Care Med 2004, 32: S513-S526. 10.1097/01.CCM.0000143119.41916.5DPubMedView ArticleGoogle Scholar
- Jimenez MF, Marshall JC: Source control in the management of sepsis. Intensive Care Med 2001,27(Suppl 1):S49-S62.PubMedView ArticleGoogle Scholar
- Amato MB, Barbas CS, Medeiros DM, et al.: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998, 338: 347–354. 10.1056/NEJM199802053380602PubMedView ArticleGoogle Scholar
- LeDoux D, Astiz ME, Carpati CM, et al.: Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 2000, 28: 2729–2732. 10.1097/00003246-200008000-00007PubMedView ArticleGoogle Scholar
- Martin C, Viviand X, Leone M, et al.: Effect of norepinephrine on the outcome of septic shock. Crit Care Med 2000, 28: 2758–2765.PubMedView ArticleGoogle Scholar
- Rivers E, Nguyen B, Havstad S, et al.: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345: 1368–1377. 10.1056/NEJMoa010307PubMedView ArticleGoogle Scholar
- Brun-Buisson C, Doyon F, Carlet J, et al.: Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. Jama 1995, 274: 968–974. 10.1001/jama.1995.03530120060042PubMedView ArticleGoogle Scholar
- Tsai MH, Peng YS, Chen YC, et al.: Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 2006, 43: 673–681. 10.1002/hep.21101PubMedView ArticleGoogle Scholar
- Moreau R, Hadengue A, Soupison T, et al.: Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome. Crit Care Med 1992, 20: 746–750. 10.1097/00003246-199206000-00008PubMedView ArticleGoogle Scholar
- Thomsen RW, Hundborg HH, Lervang HH, et al.: Diabetes mellitus as a risk and prognostic factor for community-acquired bacteremia due to enterobacteria: a 10-year, population-based study among adults. Clin Infect Dis 2005, 40: 628–631. 10.1086/427699PubMedView ArticleGoogle Scholar
- Lujan M, Gallego M, Fontanals D, et al.: Prospective observational study of bacteremic pneumococcal pneumonia: effect of discordant therapy on mortality. Crit Care Med 2004, 32: 625–631. 10.1097/01.CCM.0000114817.58194.BFPubMedView ArticleGoogle Scholar
- Mesters RM, Mannucci PM, Coppola R, et al.: Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood 1996, 88: 881–886.PubMedGoogle Scholar
- Ferreira FL, Bota DP, Bross A, et al.: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001, 286: 1754–1758. 10.1001/jama.286.14.1754PubMedView ArticleGoogle Scholar
- Moreno R, Vincent JL, Matos R, et al.: The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med 1999, 25: 686–696. 10.1007/s001340050931PubMedView ArticleGoogle Scholar
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