CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
© Thomas et al; licensee Springer. 2011
Received: 12 March 2011
Accepted: 3 October 2011
Published: 3 October 2011
Patients with acute stroke are often transferred to tertiary care centers for advanced interventional services. We hypothesized that the presence of a proximal cerebral artery occlusion on CT angiography (CTA) is an independent predictor of the use of these services.
We performed a historical cohort study of consecutive ischemic stroke patients presenting within 24 h of symptom onset to an academic emergency department who underwent emergent CTA. Use of tertiary care interventions including intra-arterial (IA) thrombolysis, mechanical clot retrieval, and neurosurgery were captured.
During the study period, 207/290 (71%) of patients with acute ischemic stroke underwent emergent CTA. Of the patients, 74/207 (36%) showed evidence of a proximal cerebral artery occlusion, and 22/207 (11%) underwent an interventional procedure. Those with proximal occlusions were more likely to receive a neurointervention (26% vs. 2%, p < 0.001). They were more likely to undergo IA thrombolysis (9% vs. 0%, p = 0.001) or a mechanical intervention (19% vs. 0%, p < 0.0001), but not more likely to undergo neurosurgery (5% vs. 2%, p = 0.2). After controlling for the initial NIH stroke scale (NIHSS) score, proximal occlusion remained an independent predictor of the use of neurointerventional services (OR 8.5, 95% CI 2.2-33). Evidence of proximal occlusion on CTA predicted use of neurointervention with sensitivity of 82% (95% CI 59-94%), specificity of 71% (95% CI 64%-77%), positive predictive value (PPV) of 25% (95% CI 16%-37%), and negative predictive value (NPV) of 97% (95% CI 92%-99%).
Proximal cerebral artery occlusion on CTA predicts the need for advanced neurointerventional services.
Regional systems of care have been established in some localities, where acute ischemic stroke patients are preferentially admitted to "stroke centers" [1, 2]. However, no formal guidelines exist for determining which patients should be transferred from a primary stroke center (PSC), capable of administering thrombolysis, to a comprehensive stroke center (CSC), with advanced services including endovascular capabilities. As a result, there can be tremendous heterogeneity in which patients remain at a PSC versus which are transferred to a CSC. Furthermore, many PSCs are likely capable of providing maximal management to stroke patients and may reserve transfer for those who need additional services available only at a CSC [3, 4].
Efficient resource allocation may best be achieved by reserving such transfers for patients who will receive the most benefit. A rapidly available tool that predicts which patients are interventional candidates would help emergency physicians determine who might benefit from transfer to a CSC.
One candidate for such a tool is CT angiography (CTA), which can reliably detect large occlusive thrombi in proximal cerebral arteries . While only 25-35% of patients with acute ischemic stroke have such occlusions, they are disproportionately responsible for high hospital costs, morbidity, and mortality [6, 7]. As intravenous (IV) recombinant tissue plasminogen activator (rtPA) is less effective in recanalizing proximally occluded vessels , these individuals may preferentially benefit from advanced therapies at tertiary care centers. In particular, intra-arterial thrombolysis [9, 10], mechanical clot disruption [11, 12], and device-aided thrombus extraction [13–15] have been shown to recanalize occluded vessels at a rate higher than for IV rtPA, which may lead to better outcome . Since multislice CT scanners are available 24/7 in the majority of US emergency departments , it may be that this technology can be harnessed to select patients for transfer.
We hypothesized that the presence of an occlusive thrombus in a proximal cerebral artery on CTA is an accurate predictor of the use of advanced neurointerventional services. We elected to perform an observational study at a center in which virtually all patients undergo emergency CT angiography as a clinical standard of care, in order to minimize selection bias.
This was an historical cohort study of consecutive ischemic stroke patients who presented to a single academic emergency department (ED) and who underwent emergent CTA. The study was approved by our Institutional Review Board.
Setting and selection of participants
All patients presenting within 24 h of symptom onset in 2006 to the ED were prospectively captured as described . This hospital is a Massachusetts Department of Public Health-certified Stroke Center and offers a full range of CSC capabilities including tertiary care interventional and neurosurgical services 24/7. Patients requiring such services were treated at our study hospital as needed without being transferred.
Although MR angiography (MRA) can also identify proximal vessel occlusion, we did not include these studies because MRI is not available in the emergency department at most hospitals  and is not a required emergent service for PSCs. However, 96% of hospitals can perform an emergency CT with contrast , and so likely have the ability to detect a proximal artery occlusion.
Standard imaging at our center for suspected acute ischemic stroke includes CTA and MRI. CT images were acquired according to standard protocols .
Classification of proximal cerebral artery occlusion on CTA imaging
The primary outcomes of interest were use of tertiary care neurointervention, including IA thrombolysis, mechanical clot retrieval or removal, or any neurosurgical procedure. We had 85% power to detect a 15% difference in the primary outcome between patients with and without proximal occlusion at the 0.05 level. Decision for the type of treatment used was based on clinical judgment of the treating cerebrovascular specialists. Secondary outcomes included need for ICU admission, length of stay, and disposition after hospital stay (categorized as discharge to home, transfer to a rehabilitation center/skilled nursing facility, or death).
As most variables were not normally distributed, univariate analyses were performed using the Wilcoxon rank sum test for continuous variables and Fisher's exact test for categorical variables. Due to the small number of outcomes, we included proximal occlusion on CTA and only one additional variable, NIHSS score, in the multivariable logistic regression model. Goodness-of-fit test and regression diagnostics were performed for influential observations. Statistical analyses were performed using STATA software version 10 (STATACorp, College Station, TX).
During the study period, 290 patients who presented within 24 h of symptom onset were admitted with acute stroke. Of these, seven were excluded for enrollment in the DIAS-2 clinical trial  since the intervention was blinded. Another 76 were excluded for not having a CTA performed (61 had MRA for cerebrovascular imaging and 15 had no vessel imaging because of contraindications to both studies), leaving 207 patients for final analysis. The median time to registration in the ED from the time last seen well was 3.9 h (IQR 2-5.8 h). Thirty-three percent of patients presented within 3 h of symptom onset, 75% within 6 h and 90% within 12 h. Of this cohort, 25% of patients received IV rtPA, 2.4% received IA thrombolysis, 6.8% received a mechanical intervention, 3.3% underwent surgery (4 decompressive hemicraniectomies and 3 carotid endarterectomies), and 52% were admitted to the neuroscience ICU.
Characteristics of patients who received advanced neurointerventional procedures*
Initial NIHSS (IQR)
Time (h) to presentation (IQR)
Proximal occlusion on CTA
Length of stay (days) (IQR)
Comparing patients with and without proximal cerebral arterial occlusion on CTA
No proximal occlusion
Time (h) to presentation (IQR)
Length of stay (days) (IQR)
Neuroscience ICU stay
Mechanical IA procedure
Predictors of need for any advanced neurointervention using multivariable analysis
OR (95% CI)
NIHSS (per unit increase)
Proximal cerebral artery occlusion
Test characteristics of proximal cerebral artery occlusion on CTA predicting need for neurointervention
Mechanical IA procedure
We found that proximal cerebral artery occlusion on CTA predicts the use of acute neurointervention. While time to presentation and neurological exam findings are often used in decision-making regarding transfers, this specific radiographic finding appears to add independent value in predicting tertiary care interventions. Use of CTA in selected patients may therefore improve our ability to stratify which patients would benefit from emergent transfer to a CSC.
Although only a quarter of patients with a proximal occlusion actually received a neurointervention, distinguishing those with a large occlusion may be important for two reasons. First, if an occlusion is not seen, it is highly unlikely that a patient will need an intervention. In fact in our study, only 3% received an intervention without a large occlusion on CTA. All of these were patients with critical internal carotid stenosis that received carotid endarterectomies that were not performed on the same day as admission but during that hospital stay. Thus, most of the patients without proximal occlusion could potentially receive appropriate care at PSCs depending upon resources available. On the other hand, if a proximal occlusion is seen on CTA, these patients should be considered for emergent transfer or at least discussed with a CSC via teleradiology or phone consultation to determine whether they are interventional candidates. Even if they are not, they might still benefit from care at a CSC because they will tend to have larger strokes, worse outcomes , and may have more complicated care needs.
The commonly used practice of relying on clinical findings and noncontrast head CT for management decisions may provide inadequate information for triaging stroke patients for advanced therapies. For example, large artery occlusive strokes may not respond well to IV rtPA, but show better response to IA therapies [20, 21]. In addition, vascular imaging provides independent information regarding the patient's prognosis . As a result, current American Heart Association (AHA) guidelines endorse vascular imaging in the initial evaluation of the patient with acute ischemic stroke symptoms .
Our data confirm findings from others that patients with proximal occlusions tend to have higher NIHSS scores [23–26]. This raises the question of whether the NIHSS score alone can select those patients requiring advanced intervention. We conclude, however, that CTA does add independent value. First, one recent prospective study found that NIHSS alone has a poor negative predictive value for proximal occlusion amenable to intervention . Second, we found that CTA provides independent information even when controlling for NIHSS. In particular, NIHSS is known to be influenced by location because it is so heavily weighted toward language function, with posterior circulation occlusions leading to a lower initial NIHSS but a worse clinical outcome [28, 29].
The major limitation of our study design is that it is a single center retrospective cohort. We chose this design for our initial analysis because our center routinely performs CTA on almost all stroke patients, minimizing selection bias. However, patients presenting to an academic center with available tertiary care services may not reflect the full range of ischemic stroke patients that present to community hospitals. More than half of the patients that had proximal occlusions on CTA or received neurointervention were transferred from outside hospitals; this likely reflects a concentrating effect providing a population of more severe strokes than that which might present to any single community hospital. While this enriched our cohort for those that achieved the primary outcome, improving our statistical power, a multicenter study in a larger cohort will be necessary to validate these findings in a more representative population. There may be logistical, financial, and ethical considerations in consenting stroke patients for CTA in other practice settings where it is not routine, but our results appear to provide justification for such a larger, prospective study of the use of CTA to guide transfer decisions.
Another limitation was the exclusion of those who were unable to undergo CTA, most often due to IV contrast allergy and renal insufficiency. While many such patients would also be excluded from interventional neuroradiological procedures, it is possible that some would still have been candidates. Also, there is the possibility that CTA, performed at centers unaccustomed to acquiring it during acute stroke or at off hours, might perform an inadequate study that could delay treatment or transfer decisions, or preclude repetition of the study at the receiving facility.
Finally, the CTA findings were used in clinical decision making, potentially confounding our analysis. This likely overestimates the association of CTA proximal occlusion and neurointervention. Unfortunately, it would likely be unethical to "blind" clinical decision makers to CTA findings. In addition, our primary goal was to aid emergency physicians in predicting clinical options that would ultimately be offered to patients, and in a real world setting such decisions are expected to incorporate all available clinical and radiographic data.
Several factors must be considered prior to incorporating the use of emergency CTA in transfer decisions. AHA guidelines highlight that decision-making regarding IV thrombolytics should not be delayed for vascular imaging such as CTA, and protocols would need to be in place to ensure that treatment decisions for IV rtPA are made prior to initiation of further imaging [1, 22]. Options can include only performing this test after IV thrombolysis in eligible patients, or only for those in whom decision-making would be changed based on the results. A rapid CTA can take less than 10 min to acquire, and the source images are available immediately on the CT scanner workstation. These images can then be rapidly processed and examined to detect proximal artery occlusion, and further studies should validate the ability of plain radiography technicians to generate the images and general radiologists or emergency physicians to reliably diagnose these occlusions. Another concern is the use of IV contrast, which can carry the risk of allergic reaction or contrast-induced nephropathy (CIN). Although traditionally thought to occur in 2-3% of cases, the risk of nephropathy after stroke or hospitalization is similar even without contrast, and many cases of CIN may simply be due to the nephropathy associated with hospitalization [30–36]. Finally, protocols should be in place to ensure that the study would not need to be repeated upon arrival to a tertiary care center, either due to an inadequate initial study or problems with image transfer between facilities. Prearranged transfer agreements, or even remote consultation via telephone or telemedicine , can ensure appropriate usage and communication.
In summary, the finding of a large proximal cerebral arterial occlusion on CTA predicts the use of neurointerventional services in patients with acute ischemic stroke. Thus, our results provide justification for conducting future prospective studies on using CTA as a rapid decision-making tool to select patients who may be candidates for endovascular therapies at CSCs.
American Heart Association
contrast induced nephropathy
comprehensive stroke center
computed tomography angiography
intensive care unit
magnetic resonance angiography
magnetic resonance imaging
NIH stroke scale
primary stroke center
recombinant tissue plasminogen activator
This work was supported by the Harvard Affiliated Emergency Medicine Residency Richard Wuerz Scholarship for Emergency Medicine Research and Public Health Service Award K23NS059774.
Patient consent was waived by the IRB since this was a retrospective review.
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