© The Author(s) 2010
Received: 21 August 2010
Accepted: 11 October 2010
Published: 6 November 2010
Acute severe methemoglobinaemia is an uncommon but life-threatening condition caused by a variety of oxidizing agents commonly used in both health care and industrial settings. Thus, recognition is important as it is readily treatable. The oxygen transport is compromised as a result of abnormal levels of oxidized haemoglobin, and this leads to skin discolouration and a variety of symptoms. Diagnostic confusion occurs as the oxygen saturations (SpO2) on the pulse oximeter are unreliable (Sharma V, Haber A. Acquired methaemoglobinaemia: a case report of benzocaine-induced methaemoglobinaemia and a review of the literature. Clin Pul Med. 2002;9(1):53–8). A case of severe methaemoglobinaemia due to self poisoning with barbicide is presented with a brief discussion of the patho-physiology and an overview of the treatment. A barbicidal overdose has never been reported before.
KeywordsBarbicide Methemoglobinaemia Methylene blue Isopropyl alcohol Benzalkonium chloride
She was tachycardic (130/min) and tachypnoeic (30/min), and had a SpO2 of 90% on 15 l oxygen; blood pressure was 100/50 mmHg. Chest examination revealed few crackles in both mid zones, and a possible chemical/apsiration pneumonitis was suspected. She had a history of deliberate self harm. She had no allergies and worked as a beautician by profession.
Arterial blood gas (ABG) analysis on oxygen showed pH 7.41 (7.35–7.45), pCO2 3.44 kPa (4.7–6), pO2 31.6 kPa (11–13 on room air), lactate 11.0 (<2), base excess −7.2 mmol/l (−2–+2) and HCO3 19.4 mmol/l (24–31). The patient continued to receive high-flow oxygen and intravenous access was gained, and bloods tests, including paracetomol and salicylate levels, and a urine toxicology for the usual drugs of abuse were requested. These subsequently turned out to be negative. She was treated with intravenous crystalloids for compensated metabolic acidosis and treated with antibiotics to cover for aspiration pneumonia. A differential diagnosis for high anion gap metabolic acidosis was worked out using the common mnemonic (MUD PILES—Methanol, Uremia, Diabetic ketoacidosis, Paraldehyde, Iron, Lactic acid, Ethanol and ethylene glycol, and Salicylates, respectively) as the anion gap was 21 (3–11). Despite her treatment, there was no sign of improvement. The initial chest x-ray was normal.
A diagnosis of methaemoglobinemia was suspected in our patient as she demonstrated (1) central cyanosis unresponsive to oxygen therapy with no previous history of congenital cardiac disease or causes for pulmonary hypertension; (2) decreased oxygen saturation on the pulse oximeter with a near normal pO2; (3) difference in the arterial blood gas (95%) and the pulse oximeter (90%) oxygen saturation measurements; and (4) she was a beautician with a history of self harm (beauty products when ingested can result in methaemoglobinaemia). An urgently requested methaemoglobin (MetHb) level showed a raised MetHb level (50.3%), which confirmed the diagnosis. She was subsequently treated with a slow intravenous dose of methylene blue (2 mg/kg). Clinical improvement was marked within 20 min. Her tachycardia and tachypnoea began to settle, and she was now able to communicate.
Her repeat ABG, 30 min post treatment, showed pH 7.37, pCO2 4.12, pO2 11.6, lactate 6.4, base excess −6.8, cHCO3 19.2 and MetHb 2.9%. She acknowledged the fact that she had consumed alcohol but refused to answer the deliberate self-harm questions. She was observed in a resuscitation room with regular ABG monitoring through an arterial line and then transferred to the intensive care unit where her recovery was complicated by the development of ARDS. ARDS was confirmed on a CT scan and was thought to be vasogenic or neurogenic in origin rather than aspiration or infective. She gradually improved and was eventually discharged from the hospital about 10 days later. Psychiatric counseling revealed that she had ingested a barbicide, and out-patient follow-up including chest clinic was arranged prior to discharge from the hospital. She was reviewed in the chest clinic for up to 3 months and had made an excellent recovery and did not have any ongoing respiratory symptoms, and hence was discharged from follow-up.
Methaemoglobinaemia should be a part of the differential diagnosis spectrum in a blue, breathless, acidotic patient unresponsive to oxygen therapy as it is a potentially fatal, yet readily treatable condition. A clue to the diagnosis is bluish discolouration of skin, and the blood has a chocolate brown colour . The diagnosis can be confirmed by requesting MetHb levels, which are mostly available in modern blood gas analysers. The sample should be analysed very soon after being drawn, as the MetHb level in the sample will decrease with time.
Haemoglobin (Hb) can accept and transport oxygen only when the iron atom is in its ferrous form (Fe2+). When haemoglobin loses an electron and becomes oxidized, it is converted to the ferric state (Fe3+) or MetHb. MetHb lacks the ability to transport oxygen. The major pathway that handles 95% of MetHb under physiological conditions is the Embden-Meyerhoff pathway in which there is an enzymatic reduction of MetHB to Hb by the enzyme NADH (nicotinamide adenine dinucleotide) MetHb reductase . Because red blood cells are continuously exposed to various oxidant stresses, blood normally contains approximately 2% MetHb levels . Methemoglobinemia may be passed down through families (inherited) or commonly acquired as a result of exposure to certain drugs, chemicals or foods (acquired). The most commonly implicated agents include dapsone, local (topical) anaesthetic agents, aniline dyes and nitrates . Anaemic patients and G6PD-deficient patients are more susceptible to methaemoglobinaemia.
10–20%, usually asymptomatic despite cyanosis
20–30%, headache, dyspnoea and anxiety
30–50%, tachycardia, dizziness, palpitaions and fatigue
50–70%, acidosis, confusion, coma and seizures
Use of methylene blue can be life-saving and is considered the treatment of choice. Methylene blue (MB), given intravenously in a dose of 1 to 2 mg/kg over 5 min, usually provides a rapid improvement in the patient’s condition; the dose may be repeated in 1 h if the level of MetHb remains high, but retreatment is frequently not necessary. Contraindications to methylene blue are G6PD deficiency and renal failure . Supplemental antioxidants such as ascorbic acid (vitamin C), N-acetylcysteine and tocopherol (vitamin E) have been used as adjuvants or alternatives to methylene blue with no confirmed benefit . Severely affected patients may benefit from adjunctive treatment with hyperbaric oxygen and/or exchange transfusion, although evidence of their efficacy is only anecdotal [8,9]. The differential diagnosis is sulfhaemoglobinemia, which refers to the inclusion of a sulfur molecule into the heme moiety. This does not respond to methylene blue treatment .
Isopropyl alcohol (IPA) is a colourless liquid with bitter taste commonly used in deicers and as a sterilising agent in window cleaners and many disinfectants. It is rapidly absorbed and reaches peak plasma levels within 30–60 min. IPA is metabolised by the enzyme alcohol dehydrogenase to acetone. Alcohols compete with IPA for this enzyme, and the average half life of IPA can be prolonged from 4 h to 16 h with co-ingestion of alcohol. Early clinical features include nausea, vomiting, abdominal pain, tachycardia, headache and dizziness. Severe poisoning can lead to haematemesis, melena, bradycardia, hypotension, dysrhythmias, hypo- or hyperglycemia, rhabdomyolysis, renal failure, respiratory depression, convulsions and coma. Clinical suspicion is raised by the sweet-smelling, fruity acetone on the breath. However, raised anion gap metabolic acidosis on the blood gas with raised osmolar gap secondary to high serum acetone levels is strongly suggestive of IPA poisoning . Treatment is usually supportive, and haemodialysis is rarely needed.
Dimethyl benzyl ammonium chloride (benzalkonium chloride) is often used as a disinfectant. Clinical features of ingestion include vomiting, diarrhoea and foaming at the mouth if the concentration is less than 10%. Higher concentrations can lead to corrosive damage to the oropharynx and the oesophagus, and should be managed accordingly. Haematemesis and circulatory collapse can also occur. Vomiting in the presence of foaming can lead to aspiration, and the foaming can be minimised with dimeticone.
Acute methaemoglobinemia is usually associated with high mortality, and an early aggressive treatment with intravenous methylene blue is potentially life-saving. A high level of suspicion with a relevant history of exposure or ingestion to a toxin or drug is often the key to the diagnosis.
- Barbicide Material Safety Data Sheet. http://www.kings-research.com/pdf/msds/Barbicide_MSDS.pdf
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