Fractured penis in a patient taking sildenafil and warfarin
© The Author(s) 2010
Received: 28 July 2010
Accepted: 1 September 2010
Published: 16 October 2010
This case of penile fracture is unique as it involves a patient taking both sildenafil and warfarin, one drug that potentiates the risk of a penile fracture and a second drug that makes the degree of bleeding and hematoma worse.
Vital signs were normal, and physical examination revealed tenderness on palpation of the pubic symphysis, profound ecchymosis, and edema extending from the lower abdomen to the perineum with absence of external injury. His INR was 1.9, which was reversed with 5 units of fresh frozen plasma given to the patient prior to being taken to the operating room.
Penile fractures were responsible for approximately 1,000 hospital admissions in the US in 2006. The average age of patients is 36, with Caucasians making up the largest demographic . A penile fracture is a traumatic rupture of the tunica albuginea of the corpus cavernosum following direct blunt trauma . An estimated 20% of patients have a concomitant urethral injury . The diagnosis of penile fracture is based on clinical grounds and is a urological emergency requiring immediate surgical consultation . Penile fracture has been reported in correlation with sildenafil use; however, it is unclear whether the relationship is causational .
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