Patients with pelvic fracture: what factors are associated with mortality?
© The Author(s) 2010
Received: 8 March 2010
Accepted: 19 July 2010
Published: 31 August 2010
Pelvic fracture is one of the major injuries that lead to death in patients who sustain high-impact injuries such as road traffic accidents and falls from height.
This study aims to look at the epidemiology and the significant predictors of mortality in victims with pelvic fracture presenting to the emergency department (ED) of an urban Asian city.
This was a retrospective data analysis of all trauma patients with pelvic fracture who were treated at the ED of an urban adult hospital in Singapore from April 2001 to December 2004. Student’s t-test and χ2 test were used in statistical analysis where appropriate.
The study included 179 consecutive patients. Sixty-four percent of patients were males, and 71% of patients were in the 20–49-year-old age group. Road traffic accidents and falls from height were the two most common mechanisms of injury. Mortality rate was 37%. Pelvic fracture severity, shock and coma at presentation, and the presence of concurrent head and chest injuries were associated with increased mortality. Gender, other mechanisms of injury and other concomitant injuries were not associated with increased mortality.
The mortality rate of trauma patients with pelvic fracture continues to be high. In such patients, predictors of mortality are the severity of the pelvic fracture, the presence of coma, shock, and head and chest injuries.
Pelvic fracture is an injury associated with high mortality in polytrauma patients [1, 2]. Its presentation may lead to rapid exanguination despite maximal resuscitative efforts . It also results in significant morbidity for patients who recover from the initial insult [4, 5]. The majority of trauma patients are young and in the prime of their lives [6–9]. It is therefore important to understand the epidemiology as well as the predictors for mortality in pelvic fracture so that preventive measures can be undertaken and preemptive treatment can be given. There is a paucity of epidemiological studies related to pelvic fracture in the Asian population. The purpose of this study is to look at the epidemiology of pelvic fracture in an Asian population and to determine factors associated with mortality.
This was a retrospective descriptive study in a 1,300-bed acute urban restructured hospital in Singapore. The study hospital has a trauma team on site, and is equipped with interventional angiography facilities and an intensive care unit. From 1 April 2001 to 31 December 2004, data of all consecutive trauma patients with pelvic fracture who presented to the Emergency Department (ED) were analysed. Data that were collected included: (1) the patient’s demographic profile, (2) assessment of physiological parameters upon presentation, (3) causes, nature and mechanisms of injury, (4) injury severity based on the Revised Trauma Score (RTS) and Injury Severity Score (ISS), (5) pelvic fracture severity (classified according to the Abbreviated Injury Score AIS), (6) the presence and severity of other concomitant injuries (classified according to AIS), (7) interventions received, (8) length of stay in the hospital including high dependency and intensive care unit and (9) survival outcome upon discharge. Student’s t-test and χ2 test were used to look for associations between variables where appropriate. Multivariate analysis using logistic regression was performed to evaluate significant predictors (determined on univariate analysis) that were associated with mortality. The significance level was set to less than 0.05. Statistical calculations were performed using STATA version 11.0 (College Station, TX). The Domain-Specific Review Board (DSRB) of the National Healthcare Group (NHG), which is the institution’s ethics committee, approved this study.
Baseline characteristics of patients
No. of patients (%) (n = 179)
Died in the ED
Died in the ward (within 24 h)
(Within 48 h)
(after 48 h)
Physiological parameters at presentation
Shock (<90 mmHg)
Coma (GCS <9)
Mechanism of injuries
Road traffic accident
Falls from height
Pelvic fracture severity (by AISb)
Presence of associated injuries
External (skin, muscle)
Odds ratios for significant predictors of mortality (on univariate and multivariate analysis)
Crude OR (95% CI)
Adjusted OR (95% CI)
Shock at presentation
Coma at presentation
Age >65 years
2.52b (0.73–8.64), p = 0.142
Presence of head injuries
Presence of chest injuries
Comparison of characteristics between patients who died and survived and the crude ORs for mortality
Age >65 years
Presence of shock
Presence of coma
Presence of head injury
Presence of chest injury
Presence of facial injury
Presence of abdominal injury
Presence of external/extemities injuries
Pelvic fracture is a serious injury that is associated with significant morbidity and mortality [4, 5]. An unstable pelvic fracture results in uncontrolled haemorrhage from the pelvic venous plexus, the tributaries of the common iliac arteries and from the fractured pelvic bones. An incredible amount of force is required to fracture the pelvis, and this can occur in road traffic accidents or from direct crushing due to a fall from height . The high kinetic energy required to disrupt the pelvis would inevitably result in other significant injuries to the trunk, head and extremities [6, 11]. Uncontrolled haemorrhage leading to shock is the main cause of mortality [1, 2, 12]. Despite the advancement of trauma research and management of pelvic fracture, the mortality from pelvic fracture remains high [1, 13].
In our study, the patients were mostly males (64%) and were aged between 20–49 years old (71%). Forty-eight percent of the male patients were motorcyclists who were involved in road traffic accidents. This demographic trend is similar to studies done in the United States [1, 6–9]. We believe that this is because male and young individuals indulge in more risk-taking behaviour . The relatively cheap price of motorcycles as compared to other vehicles in Singapore also makes them more attractive financially and readily accessible to young adults. In our data, we did not find any association between gender and the risk of mortality (χ2 test = 0.56, p = 0.45). A recent report on motorcycle safety in ASEAN countries has advocated stricter traffic regulations governing the use of motorcycles and education regarding responsible driving as two possible interventions to reduce the mortality rate .
Pelvic fracture severity is an important factor in determining the risk of mortality. In our study, the odds of dying was significantly increased when the fracture severity was at least grade AIS 4 (see Table 3). The odds of dying with severity grade AIS 4 and AIS 5 were 7.38 (95% CI 2.09–26.04) and 11.81 (95% CI 2.32–60.07, p < 0.01), respectively, compared to severity grade AIS 2 as baseline (there were no patients with fracture severity AIS 1 in our study). Various authors [6, 15] have used different scales of measurements to ascertain fracture severity (for example, Young-Burgess classification, location of fracture, stability of pelvic ring, vector of injury etc.) and have concluded that fracture severity is associated with overall injury severity, but not with mortality. Poole et al. emphasized the importance of looking for other associated injuries that might ultimately caused the patient’s demise . In our study, shock at presentation was not adjusted as a confounder in the association between pelvic fracture severity and death as it was classified (a priori) as a mediating variable in the causal pathway between pelvic fracture severity and death.
Road traffic accidents and falls from height were the most common mechanisms of injury, accounting for 52% and 44% of the study population, respectively. For patients involved in road traffic accidents, 35% were motorcyclists and 30% were pedestrians (see Table 1). Our result concurs with the trends published in the medical literature [4, 16–18]. This observation is expected as pedestrians and motorcyclists are usually not well protected, and they receive the full impact of the kinetic energy transfer. Thirty percent of motorcyclists and 39% of pedestrians died as a result of their injuries, contributing to two thirds of the overall mortality rate.
Injuries due to falls from height are related to vertical deceleration, where spinal and pelvic fractures as well as retroperitoneal bleeding are more common [19–21]. For this group of patients, at least half of them were males (53%). Of all the patients who sustained pelvic fracture from this mechanism of injury, 44% succumbed to their injuries. Interestingly, trauma due to falls from height is a unique phenomenon to Asian countries. It is an uncommon cause of pelvic fracture in the Western countries compared to road traffic accidents [1, 13]. There are a few explanations for this observation. Fang et al. discussed the association of falls from height in Taiwan with a positive history of mental disorders such as depression and schizophrenia . Unfortunately, we did not collect any data about the patients’ psychiatric history. The high concentration of high-rise residential and commercial buildings in Singapore likely contributes to the high rate of falls from height. Our analysis revealed that there was a higher proportion of patients with ISS ≥25 in the falls from height group compared to those who sustained injuries from other mechanisms (52% vs. 48%, χ2 test = 4.8, p = 0.03). Forty-four percent of fall incidents occurred in public areas, whilst 18% occurred at home. Despite the higher ISS in this group of patients, there was no significant difference in the mean systolic blood pressure or GCS between the falls from height group and those from other mechanisms. Measures that can potentially alleviate the incidence of vertical falls include increasing the awareness of mental disorders such as depression and providing adequate social support. A change in building regulations to reinforce the need for safety barriers in high-rise buildings is also warranted.
Generally, the mortality rate among patients with pelvic fractures ranges from 9–30% [8, 16, 23, 24]. In our study, the mortality rate was higher, at 37% (see Table 1). Fifty-one percent of deaths occurred in the ED. The mean ISS for our study population was 28, much higher than quoted by some authors [7, 8]. This could be due to various reasons. Firstly, the method used for capturing data may have been different. In our study, consecutive trauma patients presenting to the ED who were eligible were included in the study, whereas in other studies, patients were included only if they survived to surgical intensive care . This difference in methodology would have yielded different mortality rates. Secondly, transport time from the scene of the incident to the ED may also play a role. If the transport time was longer, more severely injured patients would have died en route to the hospital. On the other hand, if the transport time was shorter, more severely injured patients might have made it to the ED, but only to die later. The latter setting is applicable to our study, as Singapore’s ambulance services adopt the ‘scoop and run’ policy.
The presence of abnormal physiological parameters is known to predict the risk of mortality [15, 23, 25, 26]. In our study, shock and coma at presentation were strong predictors of mortality. The adjusted odds ratios for mortality for shock and coma at presentation were 4.44 and 6.69, respectively (see Table 2). As shock and coma at presentation confer very poor prognosis for patients, it is therefore imperative to prevent or delay the progression of such abnormal parameters. Training of the newer generation paramedic staff should include the recognition and management of shock at the scene of the incident .
Various studies have concluded that injuries sustained concurrently with pelvic fracture contributed significantly to mortality [6, 11]. The results of our study support this observation. Ninety-seven percent of our study population had at least one concurrent injury. Of note, patients who sustained concurrent head and chest injuries had higher odds of dying. Table 2 shows the adjusted odds ratios for head and chest injuries after taking into consideration other significant predictors of mortality. Severe chest injuries affect the respiratory mechanics of the patients, impairing gas exchange, which is vital to the body that is already volume depleted. Significant head injuries increase intracranial pressure. This further impairs the body’s attempt to cope with hypoxia and hypovolemia. It is therefore vital to adopt a multi-disciplinary approach in managing a polytrauma patient.
Pelvic fracture in the elderly provides a different challenge to the emergency physicians and trauma surgeons. The physiological changes associated with ageing make this population particularly vulnerable to injuries. Elderly patients with pelvic fracture have the worst outcomes, and they succumb to their injuries more easily despite aggressive resuscitation [10, 28, 29]. Alost et al. observed that exacerbation of the elderly’s premorbid condition is a contributory factor to mortality . In our study, patients aged more than 65 years old had a higher risk of mortality at 67% compared to the younger counterparts (χ2 test = 8.68, p = 003). This age group also has a higher proportion with ISS ≥25 (71% vs. 47%, χ2 test = 4.26, p = 0.04). The odds of dying for a 65-year-old patient with pelvic fracture was 3.96 (95% CI 1.46–10.69, p < 0.01). However, this was confounded by the presence of shock and coma at presentation. The adjusted odds ratio was 2.52 (95% CI 0.73–8.64) and was not found to be significant.
Our study is limited by its small sample size, which means that the study may not have enough power to detect small differences between groups. This problem is accentuated when stratification is done to look for the effects of confounding, as evidenced by the wide confidence intervals. The retrospective nature of our study also limits our ability to draw conclusions beyond an association of factors with mortality. Another important factor that was not considered in our study is the timing from arrival to the ED to interventions (such as external pelvic immobilization and angiography), which may behave as a confounder or an effect modifier in the association with mortality.
Pelvic fracture is a serious injury that is associated with significant morbidity and mortality. This is a result of the high energy transfer to the pelvic region. Road traffic accidents and falls from height are by far the most common mechanisms of injury. Pelvic fracture severity, shock and coma at presentation, and the presence of concurrent head and chest injuries are important predictors of mortality. It can be seen that the prevention of morbidity and mortality of pelvic fractures requires a multifaceted approach in terms of educating the public regarding injury prevention, as well as the need for paramedical and emergency care staff to recognize various prognostic factors and to mobilise resources to manage them.
I would like to thank Associate Professor Eillyne Seow and the staff of the Emergency Department, Tan Tock Seng Hospital, for their support and encouragement in making this research study a reality.
Conflicts of interest
- Grotz MRW, Allami MK, Harwood P et al (2005) Open pelvic fractures: epidemiology, current concepts of management and outcome. Injury 36:1–13PubMedView ArticleGoogle Scholar
- Durkin A, Sagi HC, Durham R et al (2006) Contemporary management of pelvic fractures. Am J Surg 192:211–223PubMedView ArticleGoogle Scholar
- Cothren CC, Osborn PM, Moore EE et al (2007) Preperitonal pelvic packing for hemodynamically unstable pelvic fractures: a paradigm shift. J Trauma 62:834–839, discussion 839-842PubMedView ArticleGoogle Scholar
- Brenneman FD, Katyal D, Boulanger BR et al (1997) Long-term outcomes in open pelvic fractures. J Trauma 42:773–777PubMedView ArticleGoogle Scholar
- Madhu TS, Raman R, Giannoudis PV (2007) Long-term outcome in patients with combined spinal and pelvic fractures. Injury 38:598–606PubMedView ArticleGoogle Scholar
- Poole GV, Ward EF, Muakkassa FF et al (1991) Pelvic fracture from major blunt trauma. Outcome is determined by associated injuries. Ann Surg 213:532–538, discussion 538-539PubMedPubMed CentralView ArticleGoogle Scholar
- Poole GV, Ward EF (1994) Causes of mortality in patients with pelvic fractures. Orthopedics 17:691–696PubMedGoogle Scholar
- Henry SM, Pollak AN, Jones AL et al (2002) Pelvic fracture in geriatric patients: a distinct clinical entity. J Trauma 53:15–20PubMedView ArticleGoogle Scholar
- Deakin DE, Boulton C, Moran CG (2007) Mortality and causes of death among patients with isolated limb and pelvic fractures. Injury 38:312–317PubMedView ArticleGoogle Scholar
- American College of Surgeons Committee on Trauma (2004) Advanced Trauma Life Support for Doctors (ATLS).Google Scholar
- Gustavo Parreira J, Coimbra R, Rasslan S et al (2000) The role of associated injuries on outcome of blunt trauma patients sustaining pelvic fractures. Injury 31:677–682PubMedView ArticleGoogle Scholar
- White CE, Hsu JR, Holcomb JB (2009) Haemodynamically unstable pelvic fractures. Injury 40:1023–1030PubMedView ArticleGoogle Scholar
- Dente CJ, Feliciano DV, Rozycki GS et al (2005) The outcome of open pelvic fractures in the modern era. Am J Surg 190:830–835PubMedView ArticleGoogle Scholar
- Per L, Al-Haji G (2005) Road safety in southeast Asia: Factors affecting motorcycle safety. Available via ICTCT. http://www.ictct.org/dlObject.php?document_nr=93&/S2_Lindskog_Al-Haji.pdf. Accessed 19 Feb 2010.
- Starr AJ, Griffin DR, Reinert CM et al (2002) Pelvic ring disruptions: prediction of associated injuries, transfusion requirement, pelvic arteriography, complications, and mortality. J Orthop Trauma 16:553–561PubMedView ArticleGoogle Scholar
- Hanson PB, Milne JC, Chapman MW (1991) Open fractures of the pelvis. Review of 43 cases. J Bone Joint Surg Br 73:325–329PubMedGoogle Scholar
- Brainard BJ, Slauterbeck J, Benjamin JB (1992) Fracture patterns and mechanisms in pedestrian motor-vehicle trauma: the ipsilateral dyad. J Orthop Trauma 6:279–282PubMedView ArticleGoogle Scholar
- Adams JE, Davis GG, Alexander CB et al (2003) Pelvic trauma in rapidly fatal motor vehicle accidents. J Orthop Trauma 17:406–410PubMedView ArticleGoogle Scholar
- Scalea T, Goldstein A, Phillips T et al (1986) An analysis of 161 falls from a height: the 'jumper syndrome'. J Trauma 26:706–712PubMedView ArticleGoogle Scholar
- Agalar F, Cakmakci M, Sayek I (1999) Factors effecting mortality in urban vertical free falls: evaluation of 180 cases. Int Surg 84:271–274PubMedGoogle Scholar
- Demetriades D, Murray J, Brown C et al (2005) High-level falls: type and severity of injuries and survival outcome according to age. J Trauma 58:342–345PubMedView ArticleGoogle Scholar
- Fang J-F, Shih L-Y, Lin B-C et al (2008) Pelvic fractures due to falls from a height in people with mental disorders. Injury 39:881–888PubMedView ArticleGoogle Scholar
- Chong KH, DeCoster T, Osler T et al (1997) Pelvic fractures and mortality. Iowa Orthop J 17:110–114PubMedPubMed CentralGoogle Scholar
- Stein DM, O'Connor JV, Kufera JA et al (2006) Risk factors associated with pelvic fractures sustained in motor vehicle collisions involving newer vehicles. J Trauma 61:21–30, discussion 30-21PubMedView ArticleGoogle Scholar
- O'Sullivan REM, White TO, Keating JF (2005) Major pelvic fractures: identification of patients at high risk. J Bone Joint Surg Br 87:530–533PubMedView ArticleGoogle Scholar
- Kido A, Inoue F, Takakura Y et al (2008) Statistical analysis of fatal bleeding pelvic fracture patients with severe associated injuries. J Orthop Sci 13:21–24PubMedView ArticleGoogle Scholar
- Lee C, Porter K (2007) The prehospital management of pelvic fractures. Emerg Med J 24:130–133PubMedPubMed CentralView ArticleGoogle Scholar
- O'Brien DP, Luchette FA, Pereira SJ et al (2002) Pelvic fracture in the elderly is associated with increased mortality. Surgery 132:710–714PubMedView ArticleGoogle Scholar
- Dechert TA, Duane TM, Frykberg BP et al (2009) Elderly patients with pelvic fracture: interventions and outcomes. Am Surg 75:291–295PubMedGoogle Scholar
- Alost T, Waldrop RD (1997) Profile of geriatric pelvic fractures presenting to the emergency department. Am J Emerg Med 15:576–578PubMedView ArticleGoogle Scholar
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