Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet
© Springer-Verlag London Ltd 2010
Received: 17 January 2010
Accepted: 15 June 2010
Published: 20 August 2010
Drug-induced hyperkalemia is not uncommon and may be life-threatening when presenting acutely in the emergency department. We present a case of severe hyperkalemia precipitated acutely by etoricoxib in a patient who was on telmisartan and a low sodium (potassium chloride-rich) diet. A 75-year-old male with a past medical history of well-controlled diabetes and hypertension was prescribed etoricoxib (90 mg daily) for 3 days for musculoskeletal backache. He had been taking his routine medications including telmisartan and a potassium-rich salt substitute for many years, without any recent change in dosage or quantity. There was evidence of microalbuminurea; however, the renal functions and electrolytes prior to starting etoricoxib were normal. He presented to the emergency department with signs and symptoms of life-threatening hyperkalemia (serum potassium 7.7 mEq/dl), accelerated hypertension, congestive heart failure, pulmonary edema and acute renal failure. Acute medical management and withholding all drugs that could cause hyperkalemia improved his serum potassium levels over 24 h and renal parameters within 5 days. All the other drugs except etoricoxib were restarted under observation over 8 weeks with no recurrence of the acute episode. Non-steroidal analgesics and other COX-2 inhibitors (rofecoxib and celecoxib) have been known to precipitate renal failure and hyperkalemia specially in patients at risk for the same; although not unexpected, this may be the first reported case of life-threatening hyperkalemia precipitated by etoricoxib in a previously stable patient having increased risk of renal failure and hyperkalemia.
KeywordsHyperkalemia Renal failure Etoricoxib NSAIDs COX2 inhibitors
Medications have been cited as a primary or contributing cause of hyperkalemia in 35% to 75% of hospitalized patients . Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with more than 10% of these cases . COX-2 inhibitors appear to have similar effects to NSAIDS via the inhibition of renal prostaglandin synthesis . The susceptibility to drug-induced hyperkalemia is higher in patients with impaired renal function, diabetes mellitus and states of impaired potassium homeostasis such as hypoaldosteronism .
Twice a day
Once a day
Once a day
Once a day
Once a day
Once a day
Insulin mixtard (30:70)
Serum urea (12–25 mg/dl)
Serum creatinine(0.5–1.2 mg/dl)
Serum sodium (136–145 meq/dl)
Serum Potassium (3.5–5.3 meq/dl)
The patient was treated 5 days prior to admission for low backache of musculoskeletal origin by his regular physician who prescribed etoricoxib 90 mg/day for 3 days. He had taken the last dose 48 h prior to presenting to us. He had complaints of nausea, weakness, lassitude, swelling of the legs and dyspnea for the last 72 h with gradually increasing respiratory distress.
On presentation our patient was afebrile, with a pulse rate of 60/min, blood pressure 180/90 mmHg, respiratory rate 30 per minute and oxygen saturation of 82% on room air. Examination showed a moist tongue, bilateral pitting pedal edema, raised jugular venous pressure and crepitations at the lung bases bilaterally.
Echocardiogram showed a left ventricular hypertrophy with a good left ventricular systolic function. Renal ultrasonogram showed no evidence of hydronephrosis, significant prostatomegaly or other masses. On fundus examination, posterior segment details were unremarkable.
There was a return of serum potassium to normal levels within 24 h. Serum sodium gradually improved over 6 days to 130 meq/dl. Serum urea decreased to pre-admission values by day 5 when he was discharged. The case was discussed with his primary physician, and with the consent of the patient, telmisartan and a low salt supplement were carefully restarted one at a time. On follow-up at 2 months, he had restarted all his previous medications including telmisartan, and his electrolyte and renal parameters were at his usual baseline levels.
The NSAID etoricoxib is a selective inhibitor of cyclo-oxygenase 2 (COX-2) approved for treatment of patients with chronic arthropathies and musculoskeletal and dental pain . Like parecoxib, celecoxib and other selective COX-2 inhibitors, it has demonstrated a significant reduction in gastrointestinal toxicity, although its renal adverse effects appear to be similar to those of other NSAIDs. The cardiovascular adverse effects of the selective COX-2 inhibitors like myocardial infarction, hypertension, fluid retention and congestive heart failure, among others, have led to a revoking of Merck’s Vioxx (rofecoxib) and the unavailability of Arcoxia (etoricoxib) in the USA [6, 7]. They are widely prescribed in Europe, South America and Asia for musculoskeletal pain. They are preferred over other NSAIDS mainly due to the favorable gastrointestinal profile and convenience of single-day dosing. It is available as an off-the-counter drug in India.
Specific COX-2 inhibition may induce renal ischemia, electrolyte imbalance and increased blood pressure, ultimately leading to fluid and sodium retention and decreased GFR . In elderly patients on a sodium-depleted diet, a drop in GFR may be significant after a single dose of COX-2 inhibitor .
In our case, acute renal insult and inhibition of prostaglandin I2 (which increases potassium secretion) as a result of COX-2 inhibition is the proposed mechanism precipitating hyperkalemia in our patient who was already on ‘low salt’ supplements rich in potassium and telmisartan, which causes hyperkalemia by inducing a state of hypoaldosteronism . The time course of events, absence of other precipitating causes of renal dysfunction or hyperkalemia, rapid improvement on stopping the drug with no recurrence on reintroduction of the other medications and diet make etoricoxib the most probable cause (Naranjo score 7).
Similar to non-selective NSAIDS, selective COX-2 inhibition may cause edema, hypertension and acute renal failure in a minority of patients. It may exacerbate pre-existing hypertension. The number and spectrum of these side effects have been greater with rofecoxib than with the other COX-2 inhibitors, presumably due to the non-class effects of these drugs as their chemical structures are different .
In 14 cases of COX-2 inhibitor (celecoxib and rofecoxib) associated acute renal failure reported by Perazella et al. , all the patients had several risk factors for NSAID-induced nephrotoxicity, including renal compromise and multiple medications. Acute renal failure, disturbances in volume status (heart failure, edema), acidosis and hyponatremia were common. Twelve patients developed hyperkalemia (>5.1 meq/dl) and four required hemodialysis. Similar to our case, treatment before the development of clinically recognized renal failure ranged from 4 days to 3 weeks, and resolution of the renal dysfunction took 2 days to 3 weeks after discontinuation of drugs and supportive therapy.
More specifically for etoricoxib, recent data from the large MEDAL (Multinational Etoricoxib vs. Diclofenac Arthritis Long Term) program, which enrolled 34,000 arthritis patients over 18 months, show clinically important increases in renal function endpoints. There was no significant increase in the incidence of hyperkalemia .
Unlike in healthy people, patients with edematous conditions requiring dietary sodium restriction and diuretics, such as those with chronic renal insufficiency, congestive heart failure, chronic liver disease and hypertension, should be treated cautiously with COX-2 inhibitors. Electrolytes and renal function should be checked 1–2 weeks after initiation of COX-2 inhibitors in these patients to screen for hyperkalemia and renal insufficiency [14, 15].
An Internet search (Google scholar and MedLine) with the words ‘hyperkalemia’/‘acute renal failure’/‘COX-2 inhibitors’/‘adverse drug reactions’ and ‘etoricoxib’ did not yield any results, making our case possibly the first such in the literature.
Even a short duration of treatment with the new COX-2 inhibitor etoricoxib may have the potential to precipitate renal failure and life-threatening hyperkalemia when administered to selected patients. The importance of considering a patient’s existing diet, medications and systemic status before writing a new prescription that may interfere with the potassium physiology cannot be overstressed.
Written informed consent was obtained from the patient (or the patient’s relatives) for publication of this case report.
The authors declare that they have no competing interests.
S.T. was involved in clinical management of the patient and in the manuscript preparation.
S.D. was involved in manuscript reviewing and editing apart from clinical patient care.
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