Treat the patient by the recognized toxidrome when the ingested herbal juice is non-toxic
© Springer-Verlag London Ltd 2010
Received: 27 September 2009
Accepted: 25 February 2010
Published: 12 May 2010
This is the case of 63-year-old mother and her 35-year-old daughter who drank herbal juice (Rhizoma Dioscoreae Nipponicae and Ficus formosana Maxim) and then developed diarrhea, cold sweating, and myoclonus. On physical examination, the mother had a normal consciousness level, a normal respiratory rate, and bilateral miosis. After the administration of 2 g of pralidoxime (PAM) and 0.5 mg of atropine, the mother felt better. The daughter only had mild symptoms of sweating and vomiting before arrival at the emergency department (ED).
The poison center of our hospital was consulted, and they assured us that the herbs ingested were all non-toxic. In conclusion, the majority of emergency physicians are not familiar with herbal medicines and plants. In this instance, however, it was more important to apply appropriate early management according to the toxidrome rather than to recognize what kind of herb had been ingested.
Usage of cholinergic agents, opiates/opioids, and sedative hypnotics, as well as pontine hemorrhage are all in the list of differential diagnoses for the causes of miosis . According to the clinical history, the patients had not taken hypnotics prior to arrival at the hospital, and there was no evidence of focal neurological signs or low respiratory rate. The mother had five episodes of watery diarrhea, persistent myoclonus, and hypotension, and a cholinergic toxidrome was highly suspected to be present in this mother and daughter. Nasogastric tube insertion and irrigation were applied, and the patients were also given 50 g of activated charcoal for gastro-intestinal (GI) decontamination. After the administration of 2 g of pralidoxime (PAM) and 0.5 mg of atropine, the mother felt better.
The patients recovered and were discharged 7½ h after close observation in the emergency department.
A toxidrome is a syndrome caused by the presence of a hazardous level of toxins in the body. It can be recognized by many clinical features, such as vital signs, consciousness level, size of the pupils, volume of secretions, motility of gastrointestinal tract, urination, and dry/wet skin. In our case, the small pupillary sizes, myoclonus, and frequent diarrhea pointed to a cholinergic toxidrome.
Most emergency physicians probably are not familiar with all herbal medicines and plants. But this case highlights the importance of applying appropriate management immediately according to the presumed toxidrome rather than recognition of what kind of herb was ingested .
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