Open Access

Meningococcemia

International Journal of Emergency Medicine20081:12

https://doi.org/10.1007/s12245-008-0012-8

Received: 27 December 2007

Accepted: 8 February 2008

Published: 15 March 2008

A 31-year-old woman without history of systemic diseases presented to the emergency department with spiking fever, chills, generalized myalgia, severe epigastralgia, and watery diarrhea for 1 day. Flulike symptoms had been noted for several days. Progressive extension of petechiae skin purpura (Fig. 1) developed within 2–3 h upon arrival at the hospital. Low blood pressure persisted despite vigorous fluid resuscitation. Laboratory results showed bandemia without obvious leukocytosis, low platelet counts, severe metabolic acidosis, and prolonged prothrombin time and partial thromboplastin time. Computed tomography of the abdomen was arranged to search for a possible intra-abdominal lesion, which could be causing the septic shock and severe abdominal pain (Fig. 2). The patient died after approximately 10 h of vigorous fluid resuscitation, inotropic agents, and antibiotics with quinolones. No emergent dialysis was arranged.
Fig. 1

Photograph of the patient showing multiple petechial spots over the abdominal wall

Fig. 2

Contrast-enhanced computed tomography of the abdomen revealed absent opacification of the renal cortex and enhancement of subcapsular and juxtamedullary areas and the medulla without excretion of contrast medium

We report a case of bilateral cortical necrosis caused by fulminant meningococcemia. Bilateral renal cortical necrosis was first described by Friedlander in 1883 [1]. It is a rare and usually irreversible cause of acute renal failure. Most cases are observed in connection with obstetric complications, but it may occur in nonobstetric diseases and concomitantly with septicemia caused by various organisms, including Neisseria meningitidis [2]. Early administration of antibiotics and plasmapheresis are the treatments of choice in the fulminant stage of meningococcemia [3].

Authors’ Affiliations

(1)
Department of Emergency Medicine, Chi-Mei Medical Center

References

  1. Friedlander C (1883) Über Nephritis scarlatinosa. Fortschr Med 1:81–89Google Scholar
  2. Chervu I, Koss M, Campese VM (1991) Bilateral renal cortical necrosis in two patients with Neisseria meningitidis sepsis. Am J Nephrol 11:411–415PubMedView ArticleGoogle Scholar
  3. Agraharkar M, Fahlen M, Siddiqui M, Rajaraman S (2000) Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis in meningococcal sepsis. Am J Kidney Dis 36:396–400PubMedView ArticleGoogle Scholar

Copyright

© Springer-Verlag London Ltd 2008

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